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The orphan nuclear receptor RORα regulates circadian transcription of the mammalian core-clock Bmal1
The protein RORalpha controls daily rhythms of the core clock gene Bmal1 in mammals
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Abstract
Loss of RORalpha protein leads to dampened circadian rhythm of Bmal1 transcription.
- BMAL1 is a key transcription factor involved in the circadian pacemaker in mammals.
- RORalpha directly activates the transcription of Bmal1 through specific response elements.
- RORalpha-deficient staggerer mice exhibit abnormal locomotor activity and unstable rhythmicity.
- In cultured cells, reduced levels of RORalpha disrupt the normal circadian rhythm of Bmal1 transcription.
- RORalpha is essential for the proper functioning of the cell-autonomous core circadian clock.
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