Full text is available at the source.
The Orphan Nuclear Receptor REV-ERBα Controls Circadian Transcription within the Positive Limb of the Mammalian Circadian Oscillator
The protein REV-ERBalpha regulates daily gene activity in the main part of the body’s internal clock
AI simplified
Abstract
REV-ERBalpha is identified as the major regulator of cyclic Bmal1 transcription.
- Mammalian circadian rhythms involve a feedback loop with positive and negative components.
- Bmal1 and Per transcription cycles operate in nearly opposite phases due to different regulatory mechanisms.
- Circadian expression of Rev-erbalpha is influenced by elements of the general feedback loop.
- REV-ERBalpha links negative limb components to the control of positive limb expression.
- While REV-ERBalpha affects clock period length and phase-shifting, it is not essential for generating circadian rhythms.
AI simplified