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Interacting Molecular Loops in the Mammalian Circadian Clock
Molecular feedback loops working together in the mammal's internal daily clock
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Abstract
In the mouse, the core mechanism for the master circadian clock involves interacting positive and negative feedback loops.
- Analysis of specific mutant mice indicates substantially altered Bmal1 rhythms.
- PERIOD2 is identified as a key positive regulator of the Bmal1 loop.
- CRYPTOCHROMES are shown to act as negative regulators for the Period and Cryptochrome cycles.
- Inhibition of CLOCK:BMAL1-mediated transcription by CRYPTOCHROME occurs through direct protein interactions, independent of other proteins.
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