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Abstract
Rhythmic expression of clock genes was observed in peripheral blood mononuclear cells, indicating significant intersubject variability.
- Clock genes are known to exist in humans, but their expression has been poorly understood.
- Peripheral blood mononuclear cells can be used to study human clock gene expression non-invasively.
- Different chronotypes of clock gene expression patterns were identified among individuals.
- Specific regulatory mechanisms may influence clock gene expression in these cells compared to other tissues.
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