Expression des gènes de l'horloge circadienne dans les cellules sanguines mononuclées humaines

Rhythmic expression of clock genes was observed in peripheral blood mononuclear cells, indicating significant intersubject variability.

• Clock genes are known to exist in humans, but their expression has been poorly understood.
• Peripheral blood mononuclear cells can be used to study human clock gene expression non-invasively.
• Different chronotypes of clock gene expression patterns were identified among individuals.
• Specific regulatory mechanisms may influence clock gene expression in these cells compared to other tissues.

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