Gene- and tissue-specific alterations of circadian clock gene expression in streptozotocin-induced diabetic mice under restricted feeding

The expression phase of the circadian gene mPer1 in peripheral tissues of diabetic mice significantly differed from that of normal mice under restricted feeding.

• Circadian genes mPer1, mPer2, and BMAL1 showed phase shifts in response to restricted feeding in both diabetic and normal mice.
• The phase shift of mPer1 in diabetic mice was notably distinct from that in normal mice when subjected to restricted feeding.
• The circadian output gene albumin D-site binding protein (DBP) experienced a complete phase shift due to restricted feeding in both groups.
• Findings suggest that endogenous insulin is not necessary for the adjustment of peripheral clocks to feeding cycles in mice.

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