Circadian clock genes and circadian phenotypes in patients with myocardial infarction

Mar 1, 2019Advances in medical sciences

Body clock genes and daily rhythm patterns in heart attack patients

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Abstract

Chronotype is associated with the ARNTL genetic variant rs12363415 in patients with myocardial infarction.

Genetic variations in circadian clock genes may influence circadian phenotypes in myocardial infarction patients.
The CLOCK gene variant rs11932595 is linked to daytime sleepiness among the patient group.
The PER2 gene variant rs934945 is also associated with increased daytime sleepiness in myocardial infarction patients.
Two independent samples were analyzed, including both MI patients and control subjects.

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PURPOSE: Human physiological activities and diseases are under the control of the circadian rhythm. There are strong epidemiological associations between disrupted circadian rhythms, sleep duration and diseases. Sleep disorders are associated with vascular outcomes, such as myocardial infarction (MI).

METHODS: We conducted an association study of genotype-phenotype interaction, to determine which circadian clock gene variants might be associated with the circadian phenotypes in patients with MI. In the present study, we analyzed the allele frequencies of 10 single nucleotide polymorphisms in four circadian clock genes in two independent samples: MI patients and controls. Chronotype was assessed using the Morningness - Eveningness Questionnaire (MEQ) and daytime sleepiness using the Epworth Sleepiness Scale (ESS).

RESULTS: Chronotype was associated with the ARNTL genetic variant rs12363415 in MI patients. The polymorphisms rs11932595 of the CLOCK gene and rs934945 of the PER2 gene were associated with daytime sleepiness in the patient group.

CONCLUSION: Our data suggest that genetic variations in some circadian clock genes might be related to circadian phenotype (i.e., chronotype and daytime sleepiness) in patients with myocardial infarction.

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Circadian clock genes and circadian phenotypes in patients with myocardial infarction

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