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A variation in the PER3 gene is linked to being a morning or evening person and to sleep timing disorders
Updated
Abstract
The minor allele of the PER3 (rs228697) is more prevalent in evening types compared to morning types.
- Single-nucleotide polymorphisms in circadian clock genes were analyzed in 182 individuals with delayed sleep phase type (DSPT), 67 (FRT) individuals, and 925 controls.
- The PER3 polymorphism (rs228697) showed a significant association with and the FRT phenotype.
- Evening types had a higher prevalence of the minor allele of rs228697, with a sex-adjusted odds ratio of 2.483.
- FRT individuals also displayed a higher prevalence of this minor allele compared to controls, indicated by an age- and sex-adjusted odds ratio of 2.021.
- These findings suggest that PER3 polymorphisms may serve as a genetic marker for circadian and sleep phenotypes.
Simplified
Key numbers
2.483
Higher Evening Preference Odds
Sex-adjusted odds ratio comparing evening types to morning types.
2.021
Allele Frequency Increase
Age- and sex-adjusted odds ratio comparing individuals to controls.