JHEP reports : innovation in hepatology

The Body’s Internal Clock Influences Liver Inflammation in MASLD

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

Circadian misalignment may contribute to the progression of Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD) toward Metabolic dysfunction-Associated Steatohepatitis (MASH).

  • The circadian clock regulates gene and protein expression as well as metabolite levels in the liver.
  • Disruption of the circadian rhythm may be linked to various metabolic disorders.
  • The connection between circadian misalignment and the progression of MASLD to MASH is not well understood.

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