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Interactions of the circadian CLOCK system and the HPA axis
Interactions between the body’s internal clock and stress hormone system
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Abstract
Dysregulation of the circadian CLOCK and stress systems may lead to pathologic conditions.
- Organisms adapt behaviorally and physiologically to day/night cycles and random stress stimuli.
- The circadian CLOCK system and stress systems consist of interconnected regulatory networks.
- Clock/Bmal1 transcription factors act as molecular pacemakers in the circadian system.
- The hypothalamic-pituitary-adrenal (HPA) axis and glucocorticoid receptor are key components of the stress response.
- Interactions between the circadian CLOCK system and the HPA axis have significant clinical implications.
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