Annals of the New York Academy of Sciences

Daily hormone cycles of the stress control system and their effects

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

The stress system may restore internal balance in organisms through neuroendocrine responses to stressors.

  • The stress response involves activation of the hypothalamic-pituitary-adrenal (HPA) axis and the locus coeruleus/norepinephrine autonomic nervous systems.
  • Daily light/dark cycles influence life through the biological clock system, which regulates gene expression patterns.
  • The CLOCK/BMAL1 transcription factor complex plays a key role in adjusting to circadian rhythms.
  • Dysregulation between the stress system and biological clock could be linked to various disorders, including metabolic, autoimmune, and mood disorders.
  • Understanding the interactions between these two systems may have clinical implications for addressing related health issues.

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Competing interests

Conflicts of interest . The authors declare no conflicts of interest.
PubMed

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