Modeling the circadian clock: From molecular mechanism to physiological disorders

May 15, 2008BioEssays : news and reviews in molecular, cellular and developmental biology

How the Body’s Internal Clock Works and Its Links to Health Problems

AI simplified

Circadian BiologyCircadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

A computational model reveals that disruptions to the circadian clock could be linked to various physiological disorders in humans.

  • Entrainment by the light-dark cycle can result in advanced or delayed sleep phase syndromes, depending on phase adjustments.
  • Lack of proper circadian entrainment is associated with non-24 hour sleep-wake syndrome, characterized by irregular sleep patterns.
  • The model suggests the potential for very long-period oscillations near the entrainment domain.
  • Chronic jet lag in mice leads to chaotic or irregular oscillations in circadian rhythms.
  • Dysfunctions of the circadian clock may contribute to disorders affecting sleep, mood, and potentially cancer.

AI simplified

Full Text

Full text is available at the source.
View full text ↗

Related papers

Feb '21
How the Body Clock Relates to Sleep Problems and Jet Lag: Findings from Computer Modeling
cited by 16 papers
research support, non-u.s. gov't
Sep '04
Modeling the mammalian body clock: testing how sensitive it is and identifying multiple rhythm mechanisms
top 50% journal
cited by 136 papers
research support, u.s. gov't, non-p.h.s.
Apr '07
Constant light during nursing causes delayed sleep patterns in mice with a Clock gene mutation
top 20% journal
cited by 13 papers
research support, non-u.s. gov't
Apr '07
PPARalpha as a possible drug target for treating sleep problems tied to body clock disruptions
cited by 64 papers
research support, non-u.s. gov't
May '03
Developing a detailed computer model of the mammal's daily biological clock
top 2% journal
cited by 464 papers
research support, non-u.s. gov't
May '09
How light and dark cycles influence the timing of the body’s internal clock
research support, non-u.s. gov't
Nov '07
Daily rhythms of seven main clock genes in six mouse body tissues
top 30% journal
cited by 75 papers
research support, non-u.s. gov't
May '06
Strength of daily body clock rhythms set by 24-hour light and dark cycles
top 50% journal
cited by 44 papers
research support, non-u.s. gov't

what lands in your inbox each week:

  • 📚7 fresh studies
  • 📝plain-language summaries
  • ✅direct links to original studies
  • 🏅top journal indicators
  • 📅weekly delivery
  • 🧘‍♂️always free

Recent issues from the circadian biology brief

issue #31
Artificial light at night disrupts bird sleep and metabolism across 675 studies
yesterday7 studies
issue #30
Your hair can reveal your circadian rhythm from a single sample
1 week ago7 studies
issue #29
Your body clock needs 25% more epidural painkiller at night
2 weeks ago7 studies
issue #28
Night owls have 123% higher mortality risk after age 81
3 weeks ago7 studies
issue #27
Light pollution linked to 31% higher diabetes risk in major analysis
4 weeks ago7 studies
issue #26
Wearables can detect early dementia signs with 70-95% accuracy across 200,000+ people
5 weeks ago7 studies
issue #25
Your brain's master clock has 7 distinct neuron types with specific jobs
6 weeks ago7 studies
issue #24
Sleep disruption in teens linked to altered circadian gene expression and future heart disease risk
7 weeks ago7 studies
issue #23
Morning-loaded eating suppresses ghrelin more than evening meals — and artificial light disrupts immune rhythms in wild rodents
8 weeks ago7 studies
issue #22
Evening people have 83% higher depression risk, while gut bacteria shape your body clock
9 weeks ago7 studies
explore the archive
See more issues from the circadian biology brief