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Circadian Clock NAD + Cycle Drives Mitochondrial Oxidative Metabolism in Mice
Daily body clock controls energy production in mouse cells through NAD+ cycle
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Abstract
Circadian control of NAD(+) bioavailability modulates mitochondrial oxidative function and organismal metabolism across the daily cycles of fasting and feeding.
- Circadian clocks synchronize cellular processes with the solar cycle, influencing metabolic activities.
- The clock transcription feedback loop produces cycles of NAD(+) biosynthesis and mitochondrial respiration.
- Modulation of mitochondrial protein acetylation is linked to the regulation of oxidative metabolic pathways.
- SIRT3 activity shows rhythmic patterns in relation to acetylation and oxidative enzyme function.
- NAD(+) supplementation in circadian mutant mice enhances oxygen consumption and restores protein deacetylation.
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