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Presence of robust circadian clock oscillation under constitutive over‐expression of mCry1 in rat‐1 fibroblasts
Strong daily clock rhythms persist despite constant high levels of mCry1 in rat fibroblast cells
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Abstract
Robust circadian clock oscillation persists even with constitutive over-expression of mCRY1 in rat-1 cells.
- mCRY proteins are critical components that negatively regulate circadian rhythms in mammals.
- The study utilized rat-1 cells engineered to express a luciferase reporter driven by the mPer2 promoter.
- Circadian clock oscillations were maintained despite the continuous accumulation of mCRY1 in the cell nuclei.
- The findings suggest that the presence of mCRY1 alone does not disrupt the circadian feedback loop.
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