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Circadian clock rhythms in different adipose tissue model systems
Daily biological rhythms in different types of fat tissue models
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Abstract
Stable circadian rhythms in adipose tissue were observed, suggesting potential for drug targeting in metabolic diseases.
- Adipose tissues exhibit 24-hour oscillations that are crucial for energy balance.
- Explant cultures from different adipose depots showed comparable luminescence rhythms indicative of circadian clock properties.
- Mature adipocytes displayed stable rhythms but with significant damping compared to pre-adipocytes.
- Rhythmic expression of key clock genes was confirmed in immortalized adipocyte cell lines.
- Maturation of adipocytes was associated with increased overall mRNA levels and amplitudes of clock genes.
- Differences in clock gene expression phases were noted between in vivo and ex vivo conditions.
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