Circadian clocks: Neural and peripheral pacemakers that impact upon the cell division cycle

Circadian clocks regulate rhythms of approximately 24 hours, functioning independently of external cues.

• Molecular circadian clocks are essential for the proper coordination of the cell division cycle.
• Interactions between circadian clocks and the cell cycle provide a framework for understanding their evolutionary relationship.
• Dysfunction of circadian timing is linked to the development of cancer.
• Disruptions in circadian rhythms, such as those caused by jet-lag or shift work, may significantly affect cell division regulation.
• The consequences of circadian disruption are important for the health of a society that operates on a 24-hour schedule.

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