Feeding and circadian clocks

The mammalian genome contains at least a dozen genes involved in regulating circadian clock feedback loops.

• The circadian system consists of multiple oscillators organized hierarchically.
• Neurons in the suprachiasmatic nuclei may drive the central circadian clock.
• Melanopsin cells in the retina capture light cues to reset the central clock.
• Peripheral clocks in tissues and organs can operate independently of the central clock.
• Circadian signals from non-photic cues can synchronize or uncouple peripheral clocks.
• Understanding the circadian clock may enhance drug and radiation therapy timing and aid in managing jet lag and night work.

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