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The interrelations among feeding, circadian rhythms and ageing
How Eating Habits, Body Clocks, and Ageing Are Connected
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Abstract
Transgenic alphaMUPA mice exhibit high amplitude, appropriately reset circadian rhythms and have a longer lifespan compared to FVB/N wild-type control mice.
- Circadian rhythms are regulated by the master clock in the brain's suprachiasmatic nuclei.
- Peripheral tissues like the liver and intestine also have their own circadian oscillators.
- Caloric restriction has been linked to lifespan extension, but its mechanisms remain largely unknown.
- The alphaMUPA mice demonstrate a spontaneous reduction in eating and an increase in lifespan.
- Reset peripheral circadian rhythms may play a crucial role in the longevity observed in calorically restricted animals.
- Caloric restriction, circadian rhythms, and lifespan could be interconnected, suggesting a novel relationship.
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