How Eating Habits, Body Clocks, and Ageing Are Connected

Transgenic alphaMUPA mice exhibit high amplitude, appropriately reset circadian rhythms and have a longer lifespan compared to FVB/N wild-type control mice.

• Circadian rhythms are regulated by the master clock in the brain's suprachiasmatic nuclei.
• Peripheral tissues like the liver and intestine also have their own circadian oscillators.
• Caloric restriction has been linked to lifespan extension, but its mechanisms remain largely unknown.
• The alphaMUPA mice demonstrate a spontaneous reduction in eating and an increase in lifespan.
• Reset peripheral circadian rhythms may play a crucial role in the longevity observed in calorically restricted animals.
• Caloric restriction, circadian rhythms, and lifespan could be interconnected, suggesting a novel relationship.

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