Effect of intermittent fasting on circadian rhythms in mice depends on feeding time

Intermittent fasting (IF) can alter circadian rhythms in mice based on the timing of food availability.

• Feeding during the light period did not disrupt the peak body temperature rhythm.
• IF resulted in nearly arrhythmic patterns of clock gene expression in the liver.
• IF advanced the expression of specific clock genes (mPer2 and mClock).
• IF restored the amplitudes of clock gene expression under disruptive light conditions, regardless of caloric restriction.
• Nighttime feeding produced rhythmic patterns similar to those seen during unrestricted feeding.

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