The suprachiasmatic nuclei are involved in determining circadian rhythms during restricted feeding

Time-restricted feeding advanced and increased the amplitude of clock gene expression in the liver across different mouse types.

• Time-restricted feeding (RF) influences clock gene expression in the liver under normal light conditions.
• In wild type (WT) mice, RF led to increased expression of mPer1, mClock, and mBmal1, while mPer2 expression decreased under ultradian light.
• The phase of clock gene expression differed between WT and alphaMUPA mice under disruptive light conditions, indicating a potential role of calorie restriction.
• Calorie restriction may contribute to resetting the circadian clock in the suprachiasmatic nuclei (SCN).
• The findings suggest a complex interaction between feeding regimens and circadian rhythms.

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