Circadian and photic regulation of clock and clock‐controlled proteins in the suprachiasmatic nuclei of calorie‐restricted mice

Timed calorie restriction (T-CR) results in phase-advancement of PER1 and AVP rhythms in mice.

• Rhythmic expression of clock proteins is altered by timed calorie restriction.
• PER1 and vasopressin (AVP) rhythms are phase-advanced in T-CR mice compared to those fed ad libitum.
• PER2 rhythm exhibits increased amplitude in T-CR mice.
• CLOCK expression is significantly reduced in T-CR mice, particularly after feeding time.
• A light pulse causes a greater increase in PER1 and PER2 expression in T-CR mice than in ad libitum-fed mice.
• Calorie restriction may modulate the regulation of the central circadian clock in response to metabolic cues.

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