Development of the light sensitivity of the clock genes Period1 and Period2, and immediate‐early gene c‐fos within the rat suprachiasmatic nucleus

Feb 19, 2009The European journal of neuroscience

Development of light sensitivity in daily rhythm genes and activity markers in the rat brain's biological clock area

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Abstract

Expression of the clock genes Per1 and c-fos is light responsive from postnatal day 1 in rats.

  • Light exposure during the subjective night induces expression of Per1, Per2, and c-fos in the suprachiasmatic nuclei.
  • Responses of Per1 and c-fos to light pulses begin to be regulated by the circadian clock starting at postnatal day 3 and day 10, respectively.
  • Per2 shows limited light responsiveness at postnatal day 3, with full gating by the circadian clock not occurring until postnatal day 5.
  • The development of light sensitivity of the circadian clock occurs gradually during early postnatal development.

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