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Light exposure during daytime modulates expression of Per1 and Per2 clock genes in the suprachiasmatic nuclei of mice
Daytime light changes daily clock gene activity in the brain’s time-keeping center of mice
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Abstract
30-minute light pulses during the subjective day generally increased levels of Per1 and Per2 mRNA in the suprachiasmatic nuclei of mice.
- Light exposure during the day affects Per1 and Per2 gene expression in nocturnal rodents.
- More pronounced increases in Per1 and Per2 expression were observed in the morning compared to other times.
- A transient decrease in Per2 expression occurred after a short light pulse applied at midday.
- Prolonged light exposure starting at midday significantly increased Per2 expression but not Per1.
- Mice exposed to a light-dark cycle showed greater daily variations in Per levels compared to those in constant darkness.
- Mice synchronized to a skeleton photoperiod exhibited reduced amplitude in daily variations of Per levels compared to those in a light-dark cycle.
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