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Phenotype of Per1- and Per2- expressing neurons in the suprachiasmatic nucleus of a diurnal rodent (Arvicanthis ansorgei): comparison with a nocturnal species, the rat
Characteristics of Two Types of Daily Rhythm Neurons in the Brain’s Timekeeping Center of a Day-Active Rodent Compared to a Night-Active Rat
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Abstract
Expression of clock genes Per1 and Per2 is mostly restricted to the dorsomedial part of the suprachiasmatic nuclei in both diurnal and nocturnal rodents.
- The study identifies the phenotype of neurons expressing Per1 and Per2 during the day in both a diurnal species, Arvicanthis ansorgei, and a nocturnal species, the rat.
- Per1 and Per2 are often coexpressed with arginine vasopressin (AVP) in the dorsomedial part of the suprachiasmatic nuclei.
- A few vasoactive intestinal polypeptide (VIP) neurons also express Per1 and Per2.
- The expression patterns of Per1 and Per2 are more distinct in the diurnal species compared to the nocturnal species.
- These findings suggest a significant role for the dorsomedial part of the suprachiasmatic nuclei in maintaining circadian rhythms.
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