The Journal of comparative neurology

Levels and light response of daily rhythm genes Per1, Per2, and activity gene c-fos in the retina of young rats

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Abstract

At postnatal day 1, the rat retina shows immediate light sensitivity with c-fos expression induced by light pulses.

  • The circadian clock genes Per1 and Per2 are expressed in the newborn rat retina from birth.
  • Light pulses trigger the expression of the immediate early gene c-fos in ganglion cells starting at postnatal day 1.
  • Initially, c-fos expression is localized to the dorsal part of the retina until postnatal day 5, after which it becomes more widespread.
  • Per1 and c-fos expression in the retinal pigment epithelium is responsive to light until postnatal day 3.
  • Per2 gene expression does not respond to light until postnatal day 10.
  • The patterns of spontaneous and light-induced gene expression in the retina evolve during early postnatal development.

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