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Circadian rhythms in behavior and clock gene expressions in the brain of mice lacking histidine decarboxylase
Daily activity patterns and brain clock gene levels in mice without histamine production
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Abstract
HDC-/- mice exhibited lower activity levels compared to wild type under both light-dark and constant darkness conditions.
- Circadian rhythms of behavior and clock gene expression were assessed in mice lacking histidine decarboxylase.
- HDC-/- mice had a significantly longer free-running period in constant darkness compared to wild type.
- mPer1 and mPer2 mRNA rhythms were disrupted in the cortex and striatum of HDC-/- mice, unlike in the suprachiasmatic nucleus.
- Histamine may play a role in the circadian system, particularly in the feedback processes linking behavior to the central clock.
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