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Behavioural rhythm splitting in the CS mouse is related to clock gene expression outside the suprachiasmatic nucleus
Splitting of daily activity patterns in CS mice is linked to clock gene activity outside the brain's main time-keeping center
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Abstract
CS mice exhibit a spontaneous splitting in their circadian rhythm of locomotor activity under constant darkness.
- Two weakly coupled oscillators may regulate locomotor activity rhythm in CS mice.
- Circadian rhythms of mPer1 and mPer2 in the suprachiasmatic nucleus (SCN) show a single peak in both split and unsplit mice.
- During rhythm splitting, mPer1 and mPer2 rhythms are slightly phase delayed relative to the activity onset, but their phase relationship remains unchanged.
- In the cerebral cortex, mPer1 and mPer2 exhibit bimodal fluctuations corresponding to split activity components, while unsplit mice show a single peak.
- No differences in mPer3 rhythms were observed between split and unsplit mice in either the SCN or cerebral cortex.
- Circadian oscillations of mPer1, mPer2, and mPer3 in the SCN are not associated with the rhythm splitting in CS mice.
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