Methamphetamine‐induced, suprachiasmatic nucleus‐independent circadian rhythms of activity and mPer gene expression in the striatum of the mouse

Oct 10, 2002The European journal of neuroscience

Methamphetamine triggers daily activity and clock gene rhythms in the mouse movement system, independent of the brain’s main internal clock

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Abstract

Acute injection of methamphetamine (MAP) resulted in elevated expression of mPer1, mBmal1, and mNpas2 genes in the striatum.

  • Daily MAP injection shifted the rhythmic expression of mPer1 and mPer2 in the striatum from nocturnal to diurnal, without affecting the SCN.
  • Lesioning the SCN flattened mPer gene oscillation in both the striatum and liver, yet daily MAP injections still produced behavioral and mPer gene expression rhythms.
  • Daily MAP injections at variable intervals (12-36 hours) did not produce a rhythmic expression of mPer genes in the striatum.
  • Findings suggest that repeated daily MAP signals may enhance the oscillatory strength of SCN-independent circadian behavioral and molecular rhythms.

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