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A new mammalian period gene predominantly expressed in the suprachiasmatic nucleus
A new daily rhythm gene mainly active in the brain’s internal clock center
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Abstract
A robust circadian rhythmic expression of the newly identified mPer2 gene is predominantly observed in the suprachiasmatic nuclei (SCN) of mice.
- mPer2 shares a similar amino acid sequence with mPer1 and Drosophila Period, suggesting it is part of the same gene family.
- Peak expression of mPer2 transcripts occurs 8 hours later in light-dark conditions and 4 hours later in dark-dark conditions compared to mPer1.
- A brief light exposure during the early subjective night causes a delayed increase in mPer2 transcripts, in contrast to the quicker response of mPer1.
- mPer2 is co-expressed with mPer1 in individual SCN cells, indicating a potential interaction between these clock genes.
- Mammalian period genes exhibit molecular diversity, which may contribute to the establishment of stable circadian rhythms.
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