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Constant light housing attenuates circadian rhythms of mPer2 mRNA AND mPER2 protein expression in the suprachiasmatic nucleus of mice
Constant light reduces daily cycles of a key clock gene and protein in the brain’s internal clock area of mice
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Abstract
mPER2 protein lost its rhythmicity in the suprachiasmatic nucleus after 7 days of constant light conditions.
- Constant light and constant dark conditions cause a free-running period and reduce activity in rodent circadian rhythms.
- The circadian expression rhythm of mPer2 mRNA in the suprachiasmatic nucleus was dampened under constant light conditions.
- In constant light, the expression peak of mPER2 protein was moderately delayed.
- Under constant dark conditions, the circadian expression of mPer2 and mPER2 protein was slightly attenuated and advanced.
- LL or DD housing did not alter mPer2 gene expression or its product in the cerebral cortex.
- The findings indicate that mPER2 circadian expression in the suprachiasmatic nucleus is associated with behavioral circadian rhythms under both light conditions.
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