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Restricted‐feeding‐induced anticipatory activity rhythm is associated with a phase‐shift of the expression of mPer1 and mPer2 mRNA in the cerebral cortex and hippocampus but not in the suprachiasmatic nucleus of mice
Restricted feeding shifts daily activity and clock gene timing in thinking and memory brain areas but not in the main body clock of mice
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Abstract
After 6 days of restricted feeding, the expression of mPer1 and mPer2 mRNA peaked during the daytime in the cerebral cortex and hippocampus.
- Daily restricted feeding can shift the timing of mPer gene expression from night-time to daytime in specific brain regions.
- Moderate mPer expression was observed in the striatum, pyriform cortex, and paraventricular nucleus, while the SCN showed no expression.
- In SCN-lesioned mice, restricted feeding still induced a rhythm of mPer mRNA expression in the cerebral cortex.
- The results suggest a connection between food-entrainable oscillations and mPer gene expression in regions outside the SCN.
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