American journal of physiology. Regulatory, integrative and comparative physiology

Daily timed feeding resets the body’s main internal clock in mice

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

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Abstract

In CS mice, the circadian pacemaker in the suprachiasmatic nucleus is entrained to a restricted feeding schedule under constant darkness.

  • CS mice exhibited wheel-running rhythms that aligned with a fixed feeding time during the restricted feeding schedule.
  • After the restricted feeding period ended, the activity rhythms in CS mice began to free run from the feeding time.
  • Clock gene expression rhythms in the SCN of CS mice maintained a consistent phase relationship with feeding time.
  • In contrast, C57BL/6J mice showed free-running wheel-running rhythms under restricted feeding conditions.
  • The circadian pacemaker in C57BL/6J mice did not entrain to feeding time but rather to their behavioral rhythms.

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