Daily restricted feeding resets the circadian clock in the suprachiasmatic nucleus of CS mice

Sep 23, 2006American journal of physiology. Regulatory, integrative and comparative physiology

Daily timed feeding resets the body’s main internal clock in mice

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Abstract

In CS mice, the circadian pacemaker in the suprachiasmatic nucleus is entrained to a restricted feeding schedule under constant darkness.

  • CS mice exhibited wheel-running rhythms that aligned with a fixed feeding time during the restricted feeding schedule.
  • After the restricted feeding period ended, the activity rhythms in CS mice began to free run from the feeding time.
  • Clock gene expression rhythms in the SCN of CS mice maintained a consistent phase relationship with feeding time.
  • In contrast, C57BL/6J mice showed free-running wheel-running rhythms under restricted feeding conditions.
  • The circadian pacemaker in C57BL/6J mice did not entrain to feeding time but rather to their behavioral rhythms.

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