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Restricted feeding entrains liver clock without participation of the suprachiasmatic nucleus
Timed eating resets the liver’s internal clock without involvement of the brain’s main timekeeper
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Abstract
Peaks of liver clock gene expression were advanced by 6-12 hours following 6 days of restricted feeding in mice.
- Restricted feeding advanced the expression of mPer1, mPer2, Dbp, and Cyp7A mRNA in the liver.
- The expression peaks in the suprachiasmatic nucleus remained unchanged by restricted feeding.
- The advance in liver clock gene expression due to restricted feeding occurred even in mice with SCN lesions.
- A 7-hour shift in the light-dark cycle also advanced clock gene expression in both the liver and SCN.
- However, changing the light-dark cycle did not affect liver clock gene expression when combined with a fixed feeding schedule at night.
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