Differential daily expression of Per1 and Per2 mRNA in the suprachiasmatic nucleus of fetal and early postnatal mice

Feb 24, 2001The European journal of neuroscience

Daily patterns of two key clock gene messages in the brain’s time-keeping center of developing mice before and after birth

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Abstract

Daily rhythms of mPer1 mRNA were observed in the fetal suprachiasmatic nucleus (SCN), while mPer2 did not exhibit such rhythms.

  • mPer1 mRNA exhibited daily oscillations in the fetal SCN on embryonic day 17.
  • mPer2 mRNA levels remained consistently high throughout the day in the fetal SCN.
  • Significant daily rhythms of mPer2 expression were observed in the SCN on postnatal day 6.
  • The expression pattern of mPer1 under constant darkness mirrored that observed in a light-dark cycle.
  • The daily oscillation of mPer1 may be linked to the rhythms of 2-deoxyglucose uptake and neuronal firing.

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