Journal of neuroscience research

Daily patterns of Per gene activity in key brain and pineal areas of aged rats

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

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Abstract

Aging is associated with reduced photic stimulation-induced expression of Per1 and Per2 in the suprachiasmatic nucleus (SCN).

  • Circadian components, including the free-running period and activity ratio, are altered with aging.
  • The core clock mechanism in the mouse SCN involves a feedback loop with Period (Per) and Cryptochrome (Cry) genes.
  • Circadian expression profiles of rPer1, rPer2, and rCry1 mRNA remain similar in young and aged rats.
  • The impairment of Per1 induction in the SCN following light stimulation may contribute to disrupted behavioral photic entrainment in aged rats.

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