Circadian profile of Per gene mRNA expression in the suprachiasmatic nucleus, paraventricular nucleus, and pineal body of aged rats

Dec 18, 2001Journal of neuroscience research

Daily patterns of Per gene activity in key brain and pineal areas of aged rats

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Abstract

Aging is associated with reduced photic stimulation-induced expression of Per1 and Per2 in the suprachiasmatic nucleus (SCN).

  • Circadian components, including the free-running period and activity ratio, are altered with aging.
  • The core clock mechanism in the mouse SCN involves a feedback loop with Period (Per) and Cryptochrome (Cry) genes.
  • Circadian expression profiles of rPer1, rPer2, and rCry1 mRNA remain similar in young and aged rats.
  • The impairment of Per1 induction in the SCN following light stimulation may contribute to disrupted behavioral photic entrainment in aged rats.

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