Ultradian feeding in mice not only affects the peripheral clock in the liver, but also the master clock in the brain

Mice on an ultradian feeding schedule that lost more than 10% body mass experienced a 3.5-hour advance in body temperature rhythm.

• Restricted feeding during the resting period shifts peripheral clocks but does not affect the central clock in the suprachiasmatic nucleus (SCN).
• Daily caloric restriction alters the SCN clock, indicated by changes in clock proteins (PER1) and vasopressin levels.
• Mice on an isocaloric ultradian feeding schedule exhibited a 1.5-hour phase-advance in body temperature rhythm while remaining nocturnal.
• Further metabolic changes under hypocaloric conditions included a larger phase-advance of body temperature rhythm and reduced PER1 expression in the SCN.
• Ultradian feeding disrupted glucose rhythmicity, but daily rhythms in liver glycogen and plasma corticosterone remained unchanged.

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