Reorganization of the Suprachiasmatic Nucleus Coding for Day Length

Apr 1, 2008Journal of biological rhythms

Changes in the brain’s internal clock system for measuring day length

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Abstract

Under long photoperiod conditions, the expression rhythms of clock genes in the mouse suprachiasmatic nucleus (SCN) show significant regional variations.

  • The expression rhythms of mPer1 and Bmal1 in the caudal SCN lead those in the rostral SCN under long photoperiod conditions.
  • In the middle SCN, the rhythms in the ventrolateral-like subdivision are advanced compared to the dorsomedial-like subdivision.
  • The mPer1::luc rhythms in the entire coronal slice from the middle SCN display two peaks with a wide peak width.
  • Imaging analysis reveals that the peak times vary widely in the rostral half of the SCN under long photoperiod conditions.
  • These regional variations in peak time are not attributed to changes in the waveform of a single SCN neuronal rhythm.

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