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Synchronization of Cellular Clocks in the Suprachiasmatic Nucleus
Coordination of individual cell clocks in the brain's daily rhythm center
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Abstract
The suprachiasmatic nucleus (SCN) exhibits a synchronized gene expression rhythm with a period length of about 24 hours.
- Clock gene transcription rhythms are synchronized across hundreds of neurons in the SCN.
- Neuronal clocks are arranged in a specific pattern throughout the SCN, indicating differential phasing.
- A protein synthesis inhibitor can reset neuronal clocks to the same phase, which is later reestablished through intrinsic interactions.
- Na+-dependent action potentials play a role in achieving and maintaining synchronization among the cellular clocks.
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