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Bimodal Clock Gene Expression in Mouse Suprachiasmatic Nucleus and Peripheral Tissues Under a 7-Hour Light and 5-Hour Dark Schedule
Two daily peaks of body clock gene activity in mouse brain's timekeeping center and other tissues under 7-hour light and 5-hour dark cycles
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Abstract
Bimodal patterns of mPer1 bioluminescence were observed in the SCN under an artificial light:dark:light:dark (LDLD) cycle.
- The mPer1 level in the ventrolateral-like subdivision of the SCN was higher during the morning photophase compared to the dorsomedial-like subdivision, with this pattern reversing in the evening.
- In the morning photophase, mBmal1 levels were higher in the dorsomedial-like subdivision than in the ventrolateral-like subdivision, with a similar reversal observed in the evening.
- Prokineticin 2 mRNA levels were reduced in both subdivisions of the SCN and did not correlate clearly with activity during the LDLD cycle.
- Liver expressions of mPer1 and mPer2 exhibited a bimodal pattern, while other clock genes did not show synchronization with the LDLD condition.
- Findings may contribute to understanding mechanisms behind splitting or bimodal rhythms related to seasonal day length measurement in mammals.
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