Full text is available at the source.
The dorsomedial hypothalamic nucleus is not necessary for food‐anticipatory circadian rhythms of behavior, temperature or clock gene expression in mice
The upper middle hypothalamus is not needed for mice to show daily food-related behavior, body temperature changes, or internal clock gene patterns
AI simplified
Abstract
A single 4-hour midday feeding after an overnight fast induced clock gene expression in the dorsomedial hypothalamic nucleus and other brain regions.
- Clock gene expression in specific brain regions was influenced by a midday feeding schedule.
- Rhythmic expression of clock genes persisted during two days of food deprivation after 12 days of scheduled feeding.
- Acute induction of certain clock genes in the DMH relied on NMDA receptor activity, while rhythmic expression after extended feeding schedules did not.
- Thermal lesions to the DMH did not impact the acute induction or rhythmic expression of clock genes in other areas of the brain following feeding.
- DMH lesions reduced overall daily activity levels and nocturnal behavior but did not affect food-anticipatory rhythms in activity or body temperature.
AI simplified