Nature neuroscience

The upper middle hypothalamus is important for daily rhythms controlled by feeding times

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

Restricted feeding synchronized daily rhythms of activity in the dorsomedial hypothalamic nucleus (DMH) of rats, with c-Fos expression peaking at mealtime.

  • The DMH is important for maintaining circadian rhythms and is influenced by food availability.
  • During restricted feeding, rats exhibited increased locomotor activity, body temperature, and wakefulness before mealtime.
  • Lesions specifically targeting DMH neurons blocked the preprandial responses in rats.
  • A correlation exists between the number of remaining DMH neurons and the degree of food entrainment observed.
  • Lesions in surrounding cell groups did not prevent food from influencing circadian rhythms.

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