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The dorsomedial hypothalamic nucleus is critical for the expression of food-entrainable circadian rhythms
The upper middle hypothalamus is important for daily rhythms controlled by feeding times
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Abstract
Restricted feeding synchronized daily rhythms of activity in the dorsomedial hypothalamic nucleus (DMH) of rats, with c-Fos expression peaking at mealtime.
- The DMH is important for maintaining circadian rhythms and is influenced by food availability.
- During restricted feeding, rats exhibited increased locomotor activity, body temperature, and wakefulness before mealtime.
- Lesions specifically targeting DMH neurons blocked the preprandial responses in rats.
- A correlation exists between the number of remaining DMH neurons and the degree of food entrainment observed.
- Lesions in surrounding cell groups did not prevent food from influencing circadian rhythms.
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