Differential role of the accumbens Shell and Core subterritories in food-entrained rhythms of rats

Feb 1, 2005Behavioural brain research

Different roles of reward system parts in daily eating rhythms of rats

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Abstract

Increased c-Fos immunoreactivity was observed in the Shell region of the nucleus accumbens mainly during feeding in food-entrained rats.

  • The Shell (Acc-Sh) and Core (Acc-Co) subregions of the nucleus accumbens may have different roles in food-entrainment.
  • c-Fos expression in the Acc-Sh region increased mainly during feeding, while in the Acc-Co region, it increased both during feeding and in anticipation of mealtime.
  • Free fatty acids (FFA) levels were entrained in both lesioned groups, but baseline levels were lower in Core-lesion rats.
  • All rats displayed food anticipatory activity (FAA), which was enhanced in Shell-lesioned animals but nearly abolished in Core-lesion rats.
  • These findings suggest a differential involvement of the accumbens nucleus in behavioral and metabolic responses to food-entrainment.

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