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Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus
Prokineticin 2 carries daily activity signals from the brain's internal clock
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Abstract
Prokineticin 2 (PK2) is rhythmically expressed in the suprachiasmatic nucleus (SCN) and may function as an output molecule of the circadian clock.
- PK2 messenger RNA levels in the SCN vary with a daily rhythm.
- The timing of PK2 expression is influenced by light exposure.
- PK2 is regulated by the circadian clock and is associated with behavioral rhythms.
- The receptor for PK2 (PKR2) is highly expressed in key regions that receive signals from the SCN.
- Delivering PK2 during the night reduces movement in rats, indicating its role in regulating circadian behavior.
- PK2 may also enhance its own production within the SCN, suggesting a local regulatory mechanism.
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