ORL1 receptor-mediated down-regulation of mPER2 in the suprachiasmatic nucleus accelerates re-entrainment of the circadian clock following a shift in the environmental light/dark cycle

Jan 2, 2007Neuropharmacology

Activation of ORL1 receptors in the brain’s circadian center speeds up adjustment to changes in the light-dark cycle by lowering mPER2 levels

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Abstract

W-212393 caused a significant phase advance of locomotor activity rhythm in mice at subjective day.

  • The circadian clock in mice can be modulated by non-photic signals, but the mechanisms are not fully understood.
  • Injection of W-212393 during subjective day led to down-regulation of the mPER2 protein in the SCN shell region, while mPer2 mRNA levels remained unchanged.
  • The phase advance induced by W-212393 did not occur in mice lacking mPer2 or ORL1 receptors.
  • Inhibition of mPER2 protein appears to accelerate re-entrainment of the circadian clock after abrupt changes in the light/dark cycle.

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