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Dissociation between Light-Induced Phase Shift of the Circadian Rhythm and Clock Gene Expression in Mice Lacking the Pituitary Adenylate Cyclase Activating Polypeptide Type 1 Receptor
Light changes daily rhythms but not clock gene activity in mice missing a key brain receptor
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Abstract
Light stimulation at early night resulted in larger phase delays in PACAP-type 1 receptor-deficient mice compared with wild-type mice.
- PACAP-type 1 receptor signaling may play a role in adjusting behavioral rhythms in response to light.
- A marked reduction in light-induced gene expression of mPer1, mPer2, and c-fos was observed in PACAP-type 1 receptor-deficient mice.
- Light stimulation at late night produced similar levels of mPer1 and c-fos gene expression in both wild-type and PACAP-type 1 receptor-deficient mice.
- While wild-type mice experienced phase advances after late-night light stimulation, PACAP-type 1 receptor-deficient mice showed phase delays.
- These findings suggest that mPer1, mPer2, and c-fos may be less critical for light-induced phase shifts at night.
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