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Mouse Period1 (mPER1) Acts as a Circadian Adaptor to Entrain the Oscillator to Environmental Light/Dark Cycles by Regulating mPER2 Protein
Mouse Period1 helps adjust the body clock to light and dark cycles by controlling Period2 protein
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Abstract
Prolongation of the lighting period by 4-16 hours induces a larger behavioral phase shift in mPer1-deficient (mPer1-/-) mice.
- mPer1-deficient mice demonstrate a slower decay of mPER2 protein (approximately 4 hours) compared to wild-type mice.
- This slower decay is associated with a larger delay in behavioral rhythm phase shifts in mPer1-/- mice.
- mPer1-/- mice are unable to adapt to long light/dark cycles under conditions with dim light or extended skeleton photoperiods.
- These findings suggest a role for mPer1 in helping nocturnal mice adjust their circadian clock to significant seasonal variations in light.
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