The European journal of neuroscience

Clock gene Per2 expression in specific rat brain areas controlled by the body’s internal clock and methamphetamine-driven rhythms

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

Methamphetamine (MAP) treatment in rats induced behavioral rhythms independent of the circadian pacemaker, with relative coordination observed in SCN-intact rats.

  • The MAP-induced oscillator (MAO) was established by administering MAP in drinking water at a specific time for 14 days.
  • Behavioral rhythms in SCN-intact rats showed phase delays under ad libitum MAP conditions, indicating a level of coordination.
  • Circadian rhythms of the clock gene Per2 were slightly advanced in the olfactory bulb, caudate-putamen, and substantia nigra of R-MAP rats compared to controls.
  • In SCN-lesioned rats, MAO phase-shifted more slowly and lacked signs of coordination.
  • Significant phase shifts in Per2 rhythms were noted in the olfactory bulb and substantia nigra of SCN-lesioned rats compared to SCN-intact rats.
  • These results indicate that extra-SCN oscillators are involved in MAO and are influenced by both MAP and the SCN.

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