Differential responses of circadian Per2 rhythms in cultured slices of discrete brain areas from rats showing internal desynchronisation by methamphetamine

Jun 4, 2013The European journal of neuroscience

Different daily rhythm patterns in brain areas from rats with disrupted internal clocks caused by methamphetamine

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Abstract

Chronic methamphetamine treatment causes significant phase shifts in circadian rhythms in specific brain areas.

  • Circadian rhythms in the parietal cortex and substantia nigra showed phase-delay shifts of 6-8 hours.
  • The olfactory bulb exhibited phase-advance shifts of approximately 8 hours.
  • Circadian rhythms in the suprachiasmatic nucleus and caudate putamen were not significantly phase shifted.
  • The period and amplitude of circadian rhythms remained unchanged following methamphetamine treatment.
  • Extra-suprachiasmatic nucleus oscillators in various brain regions may become desynchronised from the SCN due to methamphetamine.

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