Disruption of central and peripheral circadian clocks in police officers working at night.

Feb 28, 2019FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Night work in police officers disrupts body and brain internal clocks

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Abstract

In a study of 11 police officers, peripheral clocks lost rhythmicity after one week of night shifts.

Before night shifts, central clock markers were aligned to a day-oriented schedule.
After a week of working nights, centrally controlled rhythms were partially realigned but dampened.
At baseline, oral mucosa cells showed significant mRNA peaks of Period in the afternoon.
In peripheral blood mononuclear cells (PBMCs), higher expression was observed at 10:00 compared to 19:30.
Following night shifts, oral mucosa cells lost rhythmicity, and PBMCs no longer displayed the morning/evening difference.

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Working atypical schedules leads to temporal misalignments between a worker's rest-activity cycle and their endogenous circadian system. Several studies have reported disturbed centrally controlled rhythms, but little is known on shift workers' peripheral clocks. Here, we assessed central clock markers, urinary 6-sulfatoxymelatonin and salivary cortisol, and clock gene expression in 2 peripheral clocks, oral mucosa cells and peripheral blood mononuclear cells (PBMCs), in 11 police officers. Before working 7 consecutive nights, officers' centrally controlled rhythms were aligned to a day-oriented schedule. These rhythms were partially realigned to the shifted schedule and dampened after a week working nights. For peripheral clocks at baseline, Period (and nuclear receptor subfamily 1, group D, member 1 () in oral mucosa cells had a significant mRNA peak in the afternoon, whereas in PBMCs, higherexpression was observed at 10:00 compared with 19:30. After a week working nights,andexpression in oral mucosa cells lost rhythmicity, and in PBMCs, the morning/evening difference observed at baseline was lost. To our knowledge, this is the first study to demonstrate the disruption of several peripheral clocks in real shift workers. Molecular circadian disturbances are believed to have important clinical implications for the occurrence of shift work-associated medical disorders.-Koshy, A., Cuesta, M., Boudreau, P., Cermakian, N., Boivin, D. B. Disruption of central and peripheral circadian clocks in police officers working at night. PER)1-3REV-ERBα PER1-3PER1-3REV-ERBα

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Disruption of central and peripheral circadian clocks in police officers working at night.

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