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Disturbance of the Circadian System in Shift Work and Its Health Impact
Disrupted Body Clock in Shift Workers and Its Effects on Health
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Abstract
Shift workers experience significant misalignment of their circadian rhythms, with many rhythmic transcripts remaining adjusted to a day-oriented schedule even after several days of night work.
- Circadian rhythms, such as melatonin and cortisol, show limited phase shifts when transitioning from day to night schedules.
- Night-shift work disrupts the circadian system, leading to misalignment with the external light-dark cycle and internal desynchronization among various circadian levels.
- Most rhythmic transcripts in the human genome do not adapt to night schedules, resulting in dampened group amplitudes.
- Metabolomics studies indicate that metabolites typically shift by several hours during night work, causing further misalignment with circadian rhythms.
- The extensive disruptions from atypical work schedules may contribute to an increased risk of various medical conditions.
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Key numbers
1.10
Increased Odds Ratio for Metabolic Syndrome
Pooled relative risk from a meta-analysis of 21 studies.
25%
Circadian Adaptation Rate
Estimated percentage of workers adapting to night shifts.
42%
Increased Risk of Depression
Increase in risk among night workers as reported in a meta-analysis.