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Coupled network of the circadian clocks: a driving force of rhythmic physiology
Connected body clocks as a key driver of daily body rhythms
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Abstract
The circadian system consists of a hierarchically organized network of oscillators that regulate daily physiological processes.
- A 'master clock' in the suprachiasmatic nucleus of the hypothalamus synchronizes subsidiary oscillators to environmental cycles.
- Maintaining robust circadian rhythms is essential for coordinating organ functions.
- Disruption or misalignment of circadian rhythms is strongly associated with various diseases linked to modern lifestyle.
- Regulatory roles of peripheral clocks are important for cell and organ physiology.
- Circadian rhythms may influence the temporal coordination of metabolism in both health and disease.
- Methods for assessing circadian rhythmicity in humans are summarized.
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